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W.T.D.H.W.G.T.M.F.F.S.S.D.? 

What the damn hell would Gary the mother fucking friendly sea snail do?
Girl: Should we get dinner?

Guy: W.T.D.H.W.G.T.M.F.F.S.S.D.?
For Fuck's Sake

Originally used in Quake, created and defined by team OLD
(The Mike's)
You just got 'naded by a spammer.

A common reply to this might be:
F.F.S.
F.F.S. by M 2teh C April 17, 2006

O.F.F.S. 

OH for fuck sake
O.F.F.S. OH for fuck sake! My dog shit on the carpet, again!
O.F.F.S. by offs August 14, 2014

I.F.S.F.U. 

An acronym for "I Feel So Fucked Up". Can be used to refer to yourself in a emotionally or mentally draining state.
Texting:
'ngl ifsfu rn'
(I.F.S.F.U. can be combined with R.N., which is an acronym for "Right Now".)
I.F.S.F.U. by bigboigucci900 January 4, 2023

R.A.B.G.A.F.B.A.N.B.B.B.H.F.S.F.S.O.M.A.Y.H.C.T.P.T.F.O.A.S.A.R.A.N 

"Your such a R.A.B.G.A.F.B.A.N.B.B.B.H.F.S.F.S.O.M.A.Y.H.C.T.P.T.F.O.A.S.A.R.A.N"
"Penis"
stand for For F#$$ SAKES. Used in Online Games Such as CoH CoV WoW
F.F.S. I got Pwned!
F.F.S. There are way to many bosses here.
F.F.S. by QFC December 28, 2005