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1.
a word made famous by quagmire from family guy the term roofie colada is refering to a drink with a roofie in it
as you go to the bar the bartender says "So what will it be a jack and coke for you and the usual roofie colada for your date"
by Big Nutzzz December 07, 2003
 
2.
Roofie Colada was originally coined by Quagmire on Family Guy referring to a drink with a roofie in it for a female, his means of getting laid.

Over time female lushes started referring to drinks 1/2 liquor 1/2 mixer or less as Roofie Coladas.

Its first known reference in this way was seen on Facebook in early October of 2010 by a female alcohol connoisseur aka lush in the suburbs of Chicago. That post was immediately followed up with shenanigans of "Me Too" & "I Roofied Colada'd myself again last night" by other women who like to party.

Since then it's quickly caught on & took a turn for the worse when drunken idiots started making "brands" of Roofie Coladas such as Goosey Coladas which were Grey Goose w/ a splash of seltzer water & lime.

Roofie Coladas always seem like a great idea at the time and are fun for the whole family but aren't much fun the next day.
Yay it's the weekend! I need a Roofie Colada STAT.
by R-Cman October 15, 2010
 
3.
An extremely intoxicating beverage composed of half water, half vodka, and excessive amounts of Crystal Light powder. Best when shaken together in a water bottle, this sickeningly sweet concoction makes an excellent "to-go" drink and tastes virtually alcohol-free. If you don't black out, you made it wrong.
This Roofie Colada isn't strong enough. I had one sip and now I'm only a little tipsy.
by HopeRuthless March 01, 2011