Top definition
When you drink so much liquor and get so drunk, you can be declared legally retarded
"No that guys not slow, he's just so drunk he has Robert Downey syndrome"
by MissyMisery May 05, 2010
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2
When a mostly straight guy really wants to Eiffel Tower his girlfriend with Robert Downey Jr.
Girl 1: So your boyfriend, are you sure he's straight?

Girl 2: Yeah. Well, he's mostly straight. He's totally got that Robert Downey Syndrome.
by Greenspot August 22, 2015
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