When something really gets on the risky side of life making you uncomfortable with the situation.
John: Dude last night i had sex with this total slutbag and she had herpes, AIDS, Gonorrhea, Syphilis and Swine Flu.
Jim: Thats some risky biz right there bro.
Mother: Did you atleast where a condom?
John: Nope im a beast, what can I say?
Mother: That really is some super risky biz.