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1.
A raised, red rash on one's genital region, either malignant or benign, symptomatic of a sexually transmitted infection that is currently unknown to medical science.

Commonly contracted after having engaged in sexual congress with a resident of--or while oneself a resident of--Reno, Nevada.
"I was in the shower this morning and I noticed that I've got these weird bumps on my dick."
"Dude! You got the Reno Bumps?"
"What's that?"
"Nobody knows. Probably from that fat chick who got you wasted and took you home the other night!"
by El Ranchero Sucio January 11, 2013