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1.
the act of getting "dome" (aka head, fellatio, blowjob, etc.) from a girl who you do not know (generally a promiscuous female who has self worth issues and has to prove to herself she is worth anything).
Hence the "random" part of ranDOME.
"Yo Sean who was that girl you were with last night?"

"Bro I don't even know her name but she gave pretty good randome."
by Omeed June 16, 2008
 
2.
The act of getting dome from a random girl
I got some nice randome last night.
by Mongasto December 03, 2011
 
3.
(Pronounced Ran - dom - may)

Randome is a term used to describe the random appearance of manga-inspired or manga art that would show up as a result of an unrelated Google Images search. Say, for instance, you googled 'Team Fortress 2'. Team Fortress 2 is a Hat Simulator that has no basis or any relativity with Japanese art whatsoever. However, anime-inspired images of the characters appear regardless. Same goes for just about anything else, including a search of the word 'survivalist'.

While techically considered manga, 'randome' is the more accepted term because it is easier to say and it is derived from the words 'random' and 'anime'.
On Google Images, search 'survivalist'.

Looks pretty normal to me.

Scroll down to the beginning of page 3.

There you go. Randome!
by Codybean1 November 20, 2011
 
4.
the act of giving random head
I feel so slutty with all the randome I've been giving; I should really scale it back but there are so many deserving men.
by theUlTiMaTebabe February 21, 2011
 
5.
Getting head (dome) from a totally random girl you don't know.
Yeah, my girlfriend just broke up with me, so I'm gonna hit up the bar and try to fine some randome.
by FlaccidFranklin May 09, 2006
 
6.
for some reason stupid people decide to spell random with a 'e' thus making randome therefore proving that the person(s)are/is very stupid
Josh: lets make a group called 'RanDome Productions' RPD
Jeff: god damn your so stupid how the hell do you spell random wrong you dumbass
by BlackWater[FTW] October 18, 2007