Refers to a sudden intense itchy feeling of one's asshole while walking on the busy Randolf Street in downtown Chicago, IL. Due to the fact that the individual is surrounded by people, it is impossible to scratch without being embarassed, thus causing a considerable amount of pain and anguish as they walk down the street.
"Damn man I was walking to the metra and I got some insane Randolf itch all up in my ass. It was truly hell on Earth"
by Aegz September 17, 2008