Randle No Can Handle means a person can't handle the amount of weed they smoked or the amount of alcohol they consumed. The symptoms of Randle No Can Handle is when a person throws up or knocks out cold.

originated in Hawaii
Guy 1: Duuude, ty just passed out from drinking to much vodka.

Guy 2: Ahhhh randle no can handle
by FrankieDawg August 29, 2011

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