1. The act of a mother and a daughter dating/fucking a father and a son.

2. The act of penetrating a quadriplegic.
Holy jesus batman, that quadrafuck in Golden, CO was quite a dirty mess.
by Isaac from Wellington November 03, 2009

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Top Definition
(Verb)

1. To fuck something up four times
Or to say they fucked it up alot.

By fucked up, I mean screwed up or messed up.
*at party playing poker*
*spills drink on deck of cards and poker chips*
"Come on man, you quadrafucked our game!"
by Bananasweater877 July 23, 2014

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