An attempt to fancify the word "pussy". Often used by individuals attempting to sound more intelligent than they are.
Taken from the term "octopusseios" popularized by an episode of Comedy Central's "Drawn Together" where Princess Clara reveals her monsterous eight tentacled genetalia due to a curse inflicted by an evil step-mother.
Girl 1: My pusseois burns and itches like crazy!
Girl 2: Girlfriend, you need to Massengil that cooch before it gets worse.
Girl: Mom, my pusseois sometimes feels... umm, unfresh.