Top Definition
When you have a problem with a male who you interact with similar to oil and vinegar. You just don't mix with mindsets, ideals, morals, etc. They are beyond annoying and most of the time you ignore them hoping they will find someone else to bother and just poof be gone.
Deena: "Girl, what's wrong with you today?"

Shay: "I have PMS."

Deena: "Oh, damn sorry you got mad cramps?"

Shay: "No, I have man cramps as with Problematic Men Syndrome and the jerk just won't go away."
by Shani78 June 29, 2011

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