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(V.) To prioritize.

(N.) A priority.
Guy: So, are we hanging out later?

Guy 2: No, dude, I have to hang out with Lauren.

Guy: I can't believe you're going prio her over me.

Guy 2: Dude, you know you're my real prio.
by Ginsbot February 09, 2010
Originates from the ancient billy, thinking that a prio was another word for a three of a kind, a poker hand. This statement by a young hood was exploited to the max and is now used when a 3 point shot is dropped.
"Just dropped a tasty prio on ure ass!"
by Ghandez January 29, 2005