Top Definition
A feeling of depression or overall melancholy when the Holiday season has passed, having to go back to work and/or school is a major factor in Post-Holiday hangover symptoms.
John: "Hey, do you know where Phil's at?"

Susan: "Ah, he told me he was calling in sick today. post-holiday hangover got the best of him, I suppose."
by venom5517 January 03, 2011

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