Top Definition
Sometimes associated with the "Mass Effect effect", this feeling comes from the completion of the Mass Effect game series. Common causes include getting immersed so much in the game that after completion, you feel lost and/or empty, or realizing that the Mass Effect universe is so amazing compared to our own and you're pushed down by the fact that you'll never be a part of it.

To be less extreme, people may feel empty because they realize that no other game will ever be as immersive as the Mass Effect series, thus ending their gaming career forever.
A common outcome of Post Mass Effect Depression:

"No girl like Tali'Zorah nar Rayya exists in our world..."

*gunshot*
by robboelrobbo July 14, 2011

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