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1.
What happens when somebody plays the Valve game "Portal" for too long. The victim begins subconsciously imagining different aspects of the game in real life. For example, somebody with Portal Syndrome may mistake a large storage box for the Weighted Companion Cube, as as such, may begin screaming any number of things ranging from "You're alive!" to "I'm sorry I threw you into the fire!" As another example, somebody may begin thinking that they are trapped in the Aperture Science Computer Aided Enrichment Center.
Fred: Why is Lee hugging that box?

George: He has Portal Syndrome. He played Portal for seven hours straight last night.
by Meep4598 May 18, 2010
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