Top Definition
Noun. The gentle but devastating blow that hits your central nervous system courtesy of certain opiates. The pillowhammer lays you out and you stay down, because it's pretty relaxing down there.
A: "Hey did you ever notice how ...."

B: "Planning on finishing that sentence?"

A: "...Huh? Oh, sorry, pillowhammer just kicked in."

An description of the pillowhammer, taken from an article by Angie Chuang about propofol use :

"However, taking propofol was one of the most truly pleasant pharmaceutical experiences. Propofol didn’t just make me sleepy; it made me feel as if my soul had been detached from my body and was resting just above it, on a cloud of marshmallow fluff, sweet and achingly tender. It made the time I was under its influence pass in a flicker like the inside of a tunnel viewed from a bullet train, just a glimpse of darkness and lights stretched into long streaks."
by DrMexico September 16, 2009

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