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1.
Referring to abuse of prescription medication pills, typically muscle relaxers or pain medication. Also could be used in reference to selling or "dealing" pharmaceutical pills.

Most recently referenced by Charles Rogers, in his Outside the Lines interview with Jemele Hill.
"Yeah, after I re-injured my shoulder I ended up getting deep into that pill game."

"I'm off other drugs, but I'm still heavy into that pill game, son."
by shn725 September 27, 2009