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1.
noun
A green, skull-like guitar pick fasioned from one of Satans teeth. It granted the user supra-natural rock and roll abilities. Satan recently recovered this item, although he lost his right horn in the process. The horn was later shaped into a bong. The last owners of the PoD were Jack Black and Kyle Gass (Tenacious D).
I just bought Tenacious D in the Pick of Destiny on DVD. It is fuckin' hilarious.
by picolo592 March 18, 2007
 
2.
A pick wich makes u god at the guitar made out of the fucking devils penis not his horn they got it all wrong.
John: dam ur holding the devils penis dude!
Mike: no im not,(is john high again)
hobo: its the pick of destiny dumasses!
by germans77 October 21, 2007