In American football, a pick 6 is when an interception is made and returned for a touchdown (i.e., 6 points).
Tracy Porter got a pick 6 in Superbowl XLIV
by cajunchick April 30, 2010
1 more definition
A play in football where the quarterback throws an interception and the defense returns it for a touchdown
God damn it! Chris Turner threw another pick 6!
by nhl_nfl_nba October 24, 2009