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1.
A town in South Mississippi (40 miles from New Orleans/25 miles from the coast) that is known for its teen pregnancy, teen drug use and high school dropouts. At one time or another it was and may still be the highest rates in the nation. Oxycotin is also widely used here.
Afroman refers to Picayune in one of his songs.
Stay here and become like Picayune... pregnant, stoned and dumb.
by Bubble101 August 15, 2006
115 37
 
2.
The coolest place you could ever live. They really know how to play football, Roll Tide Roll ! They have a lot of super pretty girls that do NOT do drugs or get pregnant.
Are you going to the Picayune football game tonight? They will definitely win ! Roll Tide !
by ccjtbff May 14, 2009
37 70