Top definition
1. Noun, A mix of the two drinks Pepsi and Coke.

2. Noun, The word for the relationship between John Egbert and Dave Strider in the webcomic Homestuck.
1. Thanks for mixing me a Pepsicola, dude.

2. I SHIP PEPSICOLA SO HARD!
by lemonsteggy456 August 22, 2013
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