Top Definition
When you shake your fist while raising your arm, much like someone with parkinsons does when they're angry.

It's also known as the Old Man Fist Pump.
A guy cuts you off while driving, you show him the Parkinsons Uppercut!

When someone tells a bad joke, you can let them know you're going to give them the Parkinsons Uppercut, in which you'll hit them 100 times...very softly.
by Silvergun Superman June 13, 2009

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