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A disease worse than aids. When a girl has a mad sexy body but a god-awful face that makes you want to vomit your organs. See also butterface

Name is derived from the fact that one needs a paper bag to put over the chick's face
So I was going to fuck Daniella last night, but then it turned out she had paper bag syndrome.
by worsethanaids August 10, 2010
where a girl is so unbelievably hot, but then she turns around. nice ass, nice tits, nice legs; but dam is she ugly. put a bag over it. also referred to as PBS if u are standing right behind the girl in question, so as not to hurt her feelings. ugly people get hurt too..
- dam that girl has paper bag syndrome
+ i still would
by giantslaya November 13, 2005