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1.
Describes the event in which a man begins to slide his hand down the woman's panties, to pleasure her, but is blocked by the woman's hand before reaching the threshold.
"Dude, did you get some pussy last night?"

"Nahh man, she Pantie Blocked me"
by BitchYouSemenDreamin April 19, 2011
 
2.
before coytus, a man or a woman prevents a woman from getting laid whether it be intentionally or unintentionally
OMG, her best friend won't leave. She totally pantie blocked me
by BIG12594 January 31, 2011