Can be used to refer to birth defects that result from inter-familial childbirth.
I was having intercourse with Johnny, but we had to stop. I didn't know what to do with his paginis.
Person 2: Dude, you might end up with a two person threesome...
Person 1: Huh?
Person 2: Dude, she has a paginis!
-Hillary Clinton has Paginis