A combination of the Spanish words, "Padre" and "Madre," It is a bastardation of "Tu Madre" and "Tu Padre" Which are both signals of a very ugly person in the area. PaMadre is a combination of the two to signal the presence of a grotesquely, and excessively ugly individual.
"Holy crap! That acne-covered ball of lard you call your girlfriend is a PaMadre!"
by Alexei March 19, 2003