When Howard Dean was campaigning for the 2004 Presidential election he blew it during a speech. He got all excited and started naming off states he was going to win, then at a key moment he yelled PIYAAAAAAAAAAAAAW! He blew it.
This incident was parodied on Chappelle's show. It was quite hilarious.
Howard Dean: We're gonna go to New Hampshire, then Wisconsin, then Utah, then Connecticut, Then I'm gonna go home, see my wife, and PIYAAAAAAAAAAAAAAAW! PIYAW PIYAW PIYAW!