cock blocking another dude and then scoring with the broad they were trying to hook up with
McNamara's about to pick six! Nick brought Nancy home but when Mc told her that Nick has the hiv, she suddenly wanted a little Irish in her.
by The Dankl March 24, 2008
AMERICAN FOOTBALL: An interception returned for a touchdown.
SPORTS FAN 1:"Did you see Ed Reeds' PICK SIX off Tom Brady last week?"

Sports Fan 2:"Hell yeah!The Ravens'season is over.Might as well play spoiler."
by L.MARTIN November 17, 2005
A term used in football when a player of the defensive team intercepts the ball thrown by the quarterback of the offensive team and runs it back into the end zone for a 6 point touchdown. "Pick" is open to interpretation but is basically used for when the defensive player grabs the ball. The "six" is used to describe the six points earned from the touchdown.
"Did you see Kyle's pick six last night? It helped us win the game!"
by Brit Morgan October 22, 2013
Pick Six: having sex with six hot girls(that have boyfriends). it is also football terminolgy
Dude i just had a Pick Six. that was some was some awsome sex
by exthboxth November 04, 2010

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