A term used in football when a player of the defensive team intercepts the ball thrown by the quarterback of the offensive team and runs it back into the end zone for a 6 point touchdown. "Pick" is open to interpretation but is basically used for when the defensive player grabs the ball. The "six" is used to describe the six points earned from the touchdown.
"Did you see Kyle's pick six last night? It helped us win the game!"
by Brit Morgan October 22, 2013