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PGR or "Prettiest Girl in the Room" Disease is a condition that afflicts attractive women everywhere. It's characterized by the negative reaction a pretty girl expresses when she meets a girl that's prettier than her, rendering her "not the prettiest girl in the room" anymore.
Girl 1: Mandy, you look lovely as always. I'd like you to meet my friend, Sexy Withoutmakeup.

Girl 2: I don't like her.

Girl 1: You just met her, why not?

Girl 2: She's dressed like a whore.

Girl 1: Oh, you're just being jealous. You've got PGR Disease.
by rhastings88 February 24, 2014
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