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3.
pfo
acronym for PERMANENTLY FUCKED OFF

meaning if you're pfo'd you are permanently fucked off. aint got nothing coming. you fucked yourself. ;)
you're pfo dude. you crossed the line and there aint no going back.
by urworstnitemareagin April 24, 2011
 
1.
PFO
A rejection letter received after an unsuccessful job interview. Also applicable for any polite-but-final rejection.

Origin: An acronym of "Please F--k Off"
"Remember we auditioned for the Middle-a-nowhere opera company last week? Did you hear back from them yet?"

"Yeah, I got a PFO a couple of days ago."
by Ken Hoover February 20, 2004
 
2.
PFO
Please Fuck Off

A polite but demeaning and contentious way of telling another person to simply 'fuck off'.
Via text message:

Paul: Can i take you on another date?
Martha: No.
Pauk: Please, i promise not to grab your tit again.
Martha: PFO.
by Ray_Bens December 28, 2012
 
4.
pfo
An explanation of injuries resulting from a drunken accident.

Abbreviation of "Pissed, Fell Over" (in the British / Australian usage)
"Hey, what happened to you? How did you get those bruises all over your knees?"

"Oh you know, the usual - Saturday night PFO!"
by jumbelina January 28, 2008
 
5.
pfo
Paranoid Freak Out. An episode of mental hysteria, brought on by ingesting a cocktail of psycoactive drugs.
"That Scottish Cunty was having another PFO"
by Dark Mark.com March 13, 2008
 
6.
pfo
An acronym for "pass the fuck out"
"I gonna pfo, I've been awake for more than 24 hours"

I'm gonna go home and pfo."
by randomname11 May 26, 2008
 
7.
pfo
Paranoid Freak Out. An episode of mental hysteria, brought on by ingesting a cocktail of psycoactive drugs.
"That Scottish Cunty was having another PFO"
by Dark Mark.com March 13, 2008