An acronym from the words Pool Of Fuckbuddies. Having a P.O.F. means that you can broadcast a single generic booty call message (for example, an SMS) via technological device to many possible fuckbuddy candidates.
Jared sent an SMS to his P.O.F. reading "Hi precious <3 My balls are so full that they hurt, do you happen to know any ailment for that ;)) -J."