Top Definition
A reduplicative diminutive of oy expressing frustration or exasperation.

Variant spelling: oi yoi yoi
Slipping down in his hospital bed, Grandpa Vince says upon seeing his son, "Oy yoi yoi."

Boston Legal. The Good Lawyer. Season 3, Episode 16. Teleplay by David E. Kelley.
Bethany Horowitz: "Oy yoi yoi. Just do it."

Painting by Roger Hilton at the Tate Gallery in Britain: Oi Yoi Yoi (1963)
by Paleohippie June 11, 2008
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