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When a chick, who is usually fat, gets skinny, then fat than skinny again. But she always ends up fat for a while, suffering from not being able to stay skinny. Named for Oprah's constant wait loss and eventaul regain.
Ted: That cow Hillary is fat again! She was skinny last week!
Pat: Poor bitch has Oprah Winfrey's Disease! She can't keep the wait off.
by APT October 12, 2005
120 62

Words related to Oprah Winfrey's Disease

oprah disease fat oprahed oprahfried oprah moment weight whole other oprah winfrey