(1)Complete reversal of previous positions on important or trivial matters affecting everyday life ... normally but not necessarily appearing when one turns 50+ ...

(2)Suddenly giving up on previously held beliefs ... Flipping-flopping on a given issue ...
Bob is a peace activist his entire life, but while on his death bed, he decides that conflict is a necessary action of humanity, he is obviously suffering from "Old Man Derangement Syndrome".

Fran is a life long Republican, but when she turns 60 years old, Fran becomes a Democrat, throwing away long .held political beliefs.

Jim believes in marriage being between a male and female, but in his later years of life, decides marriage can be between a male and female, a male and male, or a female and female.
by HatesOldManFlipFlopping May 28, 2012

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