Top Definition
To behave in an extreme, inappropriate manner in response to provocation.
When he heard he just went 'off on one' and wouldnt stop ranting for several hours.
by terminal.eight March 05, 2006

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Behaviour outside the realms of normal, with respect to the individual.

To do one's own thing.

To 'give the birdie' to the world and make a concerted effort to annoy / piss off / offend as many people as possible in a given timeframe.
John: Er... is Calvin off on one?
James: Nope - he usually chases pigeons on his lunchbreak.

James: Woah - does Miranda usually dance on tables whilst inebriated, sans underwear??
John: Nope - she's off on one.
by mr. duffy March 07, 2010

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One side has the word, one side has the definition. Microwave and dishwasher safe. Lotsa space for your liquids.

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The Urban Dictionary T-Shirt

Soft and offensive. Just like you.

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The Urban Dictionary T-Shirt

Smooth, soft, slim fit American Apparel shirt. Custom printed. 100% fine jersey cotton, except for heather grey (90% cotton).

Buy the t-shirt