Top Definition
OPE
1: A reaction for something small but silly happening.

2: Said after a witty remark.
Ex.1: General. OPE!

Ex.2:

P1: Fatty says what?
P2: What?
P1: OPE.
by Niko Jims January 09, 2010

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Opium or any opiate/opioid (oxycodone, codeine, hydrocodone, heroin, morphine, fentanyl.. whatever)
"I could really go for some opes right now"

"OOOOPPPPEEEEESSSS" (to be said in a raspy ope-voice while under the influence)
by abeeler February 21, 2008

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(noun) -An interjection of surprise after an unexpected event occured. It can be for either bad or good connotation depending on the situation.
You and a friend are fighting over an ice cream cone and it slips out of your hands and lands on your dogs head, so you and your friend look at each other and say, "Ope!"
by YaMommasDaddy January 18, 2012

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or 'opez', used as replacement for 'oops' as in when one makez a mistake.

bobz: nice beat mane, itz hot.

jimmz: i didn't make it mane.

bobz: opes, my bad.
by John3:30 March 02, 2009

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ope
Another name for the drug opium
You down with ope?

You know it!
by davethelurker September 20, 2006

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ope
no longer do you have to choose between the words ape and oaf, ope is a word that encapsulates both!
Jonny wilds is an Ope
I behaved like an Ope last night
by David O'Connor October 07, 2007

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ope
A instinctive reaction when you see a chick and you immediately know you would.

Often followed by staring at said chick with hand in a fist shape covering ones mouth.
:See a fine chick walking:
OPE! She go!
by Amoneyies August 05, 2010

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