Top definition
1: A reaction for something small but silly happening.

2: Said after a witty remark.
Ex.1: General. OPE!

Ex.2:

P1: Fatty says what?
P2: What?
P1: OPE.
by Niko Jims January 09, 2010
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2
Opium or any opiate/opioid (oxycodone, codeine, hydrocodone, heroin, morphine, fentanyl.. whatever)
"I could really go for some opes right now"

"OOOOPPPPEEEEESSSS" (to be said in a raspy ope-voice while under the influence)
by abeeler February 21, 2008
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3
(noun) -An interjection of surprise after an unexpected event occured. It can be for either bad or good connotation depending on the situation.
You and a friend are fighting over an ice cream cone and it slips out of your hands and lands on your dogs head, so you and your friend look at each other and say, "Ope!"
by YaMommasDaddy January 18, 2012
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4
or 'opez', used as replacement for 'oops' as in when one makez a mistake.

bobz: nice beat mane, itz hot.

jimmz: i didn't make it mane.

bobz: opes, my bad.
by John3:30 March 02, 2009
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5
This word is an exclamation, used to convey the sense of having forgotten something and then suddently remembered.
"Ope! I need to tell you.."

or
(brief silence) "Ope! I forgot!"
by Wallaby April 18, 2005
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6
It's a Midwest thing. When someone cuts in front of you rudely, when you are surprised, when you bump into someone, or when something is offensively funny, you use the word ope.
Boss: You're getting a promotion

You: Ope, really? Thank you so much

*bumbs into someone at the mall*
You: Ope sorry my bad
via giphy
by aannettec July 06, 2017
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7
Another name for the drug opium
by davethelurker September 20, 2006
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