Top Definition
To be under the influence of meth or a similar substance.
Damn,man!I saw that fool Kyle the other day,homie....That fool was on a hot one!
#meth #spun-out #on a fresh one #gacked #tweaked
by LbcSlim1 December 20, 2007
5 Words related to ON A HOT ONE!
In the middle of a hot crime spree.
That westside crew is on a hot one!
by Caroline Byrne August 23, 2005
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