Top Definition
To be under the influence of meth or a similar substance.
Damn,man!I saw that fool Kyle the other day,homie....That fool was on a hot one!
by LbcSlim1 December 20, 2007

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In the middle of a hot crime spree.
That westside crew is on a hot one!
by Caroline Byrne August 23, 2005

The Urban Dictionary Mug

One side has the word, one side has the definition. Microwave and dishwasher safe. Lotsa space for your liquids.

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