Top Definition
Another slang word for OXYCONTIN...
Are we going to take an o-sizzle rail to our dome piece?!?!
by Susan Miller March 18, 2008
Pronounced- "Oh-sizzle"

Street name for the prescription painkiller Oxycontin. It is a fast-growing drug that, when crushed and snorted, produces similar effects to Heroin.
Yo, got any Osizzle for me?
by smartestalex September 30, 2007
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