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1.
a modification of the word "Yup"

1) well said
2) said in a agreement
3) can be used as a greeting, hey whats up
1..and 2...Yo u goin to PartyMarty's tonite....Nyup!
Guy: Dude, you think that chick's hot?
Dude: Nyup!

Guy: Dude, OMG, these bacon wrapped hot dogs are the shiz!
Dude: Nyup!
by PartyMartyMcFly May 02, 2008
 
2.
Nyup:

1. sarcastically agreeing with the previous statement;
2. meaning = not a chance; yea right; etc.
Person: (while looking at vomit) "That smells so good.. Nyup"

Girl with flat chest walks by..
Person: I wish my breasts were as big as hers.. nyup

Person A: (while looking at self in mirror in a dressing room wearing a dress that is 2 sizes too small she tells Person B) "I'll fit into this dress by Saturday."
Person B: "Nyup"

Person: Lindsay Lohan is a great role model.. nyup

Person: The world's going to end 12/21/12
Person B: NYUP

Kid playing instrument for first time
Mom:Sounds great hunny!!! .. nyup(says under breath)
by artartartar January 05, 2012