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2.
Literally means, "don't stain". but its metaphoric meaning is somewhat like saying "stop kidding" or "are you serious?(rhetorically speaking)"
Ryan: Dude, my girlfriend slapped me in the face before i broke up with her.

Omar: no manches dude.

Ryan: true story.
by Paras Nuevo Leon April 28, 2009
 
1.
Mexican Castellano idiom for stop kidding around, " don't jerk my chain ", No Way or whatever.
"No manches, are you really going to cross the border illegally?"
by Paco Rivera March 16, 2005
 
3.
Means: "dont stain", but also known as "Don't bug me"
Get up dude, its already noon!
Response: No Manches!

Bartendar: "Last call!"
Drunk Girl:"Como manches!"
by Cecedawg May 26, 2006