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After a sentence, either sarcastic or serious when people have started laughing, use 'No seriously' to either show

A) You're serious and want them to stop laughing because it's not funny
B) You're taking the piss out of them by not being serious
Amy "Hey Ashlee, do you want to come with me and my extended family to woop woop for a month or two? It'll be super fun!"
Ashlee (laughs) "Yeah, a month or two in woop woop with your extended family will be super fun!"
Amy (pissed off) "No, seriously. I think I'll go ask Sarah. (under her breath) Bitch."

Jim "Dude, last night I had a totally rippin' threesome with Carmen Electra and Jessica Simpson!"
Joe (laughs) "Like fuck you did"
Jim (laughs) "No, seriously. I jacked off alone to Judge Judy."
Joe (disgusted) "Oh, dude" (leaves)
by Kateus December 29, 2005

Words related to No, seriously

woop woop pissed off sarcasm sarcastic serious taking the piss