Top Definition
Old timer's vernacular, used to express disbelief or disagreement. You can also use it to say "no" to someone named Jose.
Nancy: Fred, I'm pregnant.
Fred: No way, Jose!

Jose: Dude, can I borrow ten bucks?
Mike: No way, Jose.
by sammabanana August 19, 2007
5 Words related to No way, Jose!

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