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1.
1. Interjection used to express disbelief at an understatement. Obviously; no shit.

2. Statement used to express general agreement with a friend. Fuckin' A'; for real; I heard that.

(Chet can be dropped in any usage)
1. Bill: Your leg is on fire!

Tim: No guff, Chet!

2. Carl: We really stepped in it this time.

Joe: No guff.
by squeezmunky February 13, 2010