Top Definition
A bizarre disorder where the owner of a car, often a Nissan, has a tendency to hug the dotted line of a divided highway, occasionally drifting into the other lane, other times making it almost impossible to pass the sufferer.
Dude 1: "Dude, that douche just spent half an hour practically riding the center line, and he just shifted lanes without signaling!"

Dude 2: "Textbook Nissan Disease"
by JawshBawkes February 05, 2011
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