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Niš is a city in Serbia and one of the oldest cities in the Balkans, and has from ancient times been considered a gateway between the East and the West.
Constantine I, ruler of the Byzantium empire (4th century) was born at Naissus, (today called Nis, Serbia)
by CrnaStrela September 05, 2005
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2
All these girls on my nis
by Graham Morgan January 20, 2004
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3
A reference to Male Genitals and Anus based on context.
ex. 1: Hey babe, wanna do it in the nis? (anus)
ex. 2: Dude, look at my giant nis! (penis or anus)
ex. 2: She totally just polished my nis (penis)
by this nis dudes December 12, 2009
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The vengeful act of crapping on a lover's chest while they sleep.

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4
Hey Melissa, are you gunna get some of that 'nis tonight?
by EvilSp0rk April 12, 2006
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5
"Non-Interactive Scene"
Primarily used in the games industry to describe a cutscene where the players control of the character has been temporarily deactivated to watch a series of events.
Dude, did you see that NIS where that zombie jumps out the hallway and knocks you down the stairs? I totally papped myself.
by Gimble Shanks July 14, 2006
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6
1) of or relating to your personal space
2) an object or task that you cannot describe with English words

Other variation: nis-nis
"She was all up in my nis."
or
"We'll do the nis-nis and then get a sandwich."
by Amy D. April 25, 2005
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7
A shortened, slang version of penis. Meant to be in the style of ridiculous 1980s slang most likely said by some in the Valley of California.

Origin: South Side of Chicago neighborhood Mount Greenwood
"Ah man, she hit me in the nis!"
by Dave Losso November 11, 2007
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