Top Definition
Nis
Niš is a city in Serbia and one of the oldest cities in the Balkans, and has from ancient times been considered a gateway between the East and the West.
Constantine I, ruler of the Byzantium empire (4th century) was born at Naissus, (today called Nis, Serbia)
by CrnaStrela September 05, 2005

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nis
another word for penis
All these girls on my nis
by Graham Morgan January 20, 2004

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Nis
A reference to Male Genitals and Anus based on context.
ex. 1: Hey babe, wanna do it in the nis? (anus)
ex. 2: Dude, look at my giant nis! (penis or anus)
ex. 2: She totally just polished my nis (penis)
by this nis dudes December 12, 2009

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Shorthand for penis.
Hey Melissa, are you gunna get some of that 'nis tonight?
by EvilSp0rk April 12, 2006

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NIS
"Non-Interactive Scene"
Primarily used in the games industry to describe a cutscene where the players control of the character has been temporarily deactivated to watch a series of events.
Dude, did you see that NIS where that zombie jumps out the hallway and knocks you down the stairs? I totally papped myself.
by Gimble Shanks July 14, 2006

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nis
1) of or relating to your personal space
2) an object or task that you cannot describe with English words

Other variation: nis-nis
"She was all up in my nis."
or
"We'll do the nis-nis and then get a sandwich."
by Amy D. April 25, 2005

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nis
Abbreviated version of penis. Slang.
"You are such a nis head"
by scoophead November 29, 2009

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