look up any word, like columbusing:
 
1.
When a woman ices (or at minimum, perks) her nipples before going out. She does this to look super duper hot.
That girl's looking smoking. See her nips? She probably did nipple up. Yeah, she probably nippled up.
by jgarner3999 February 08, 2010
 
2.
get tough, step up to the plate, it is the female equivalent of nut up or sack up
She needs to nipple up and tell that guy what time it is.
by drbillyg May 19, 2014