Top Definition
When one's thumb and index finger grasps the victim's nipples resulting in a whale of pain. If a victim experiences nipple twisters often enough in his/her run of existence, he/she may have nipple cancer.

Nipple twisters are mainly given to males, often by males. But there is an occasional pervert who decides to bestow a nipple twister to the head cheerleader of the school, who happens to have her boyfriend behind her. Ouch...
Justin: When I was your age, I was given nipple twisters daily, today, I am dying from breast cancer... I'm 28.

Tanner: Shitty...
by QcQc June 04, 2009

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