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1.
A substance that is in some way superior or more powerful than others
Example 1:

"I just got some Puerto Rican rum. It's some next level shit"

Example 2:

Person A: "That guy's all fucked up"
Person B: "Yeah, he's high on some next level shit"
by Mac 7 July 06, 2009
 
2.
(N.) Refers to some of the most dank weed around. This weed is far superior reggs or middies, and contains very high levels of THC.

(V.) To be high on incredibly dank weed.
Person #1: Yo guess what I just scored.

Person #2: Some reggs?

Person #1: Nah, I got some of that Next Level Shit! It's some Purple Kush.

Person #3: Damn we're gonna be on some next level shit tonight.
by Ace_Go_Blue March 22, 2010